Key result
Diabetes mellitus was independently associated with greater ejection fraction improvement (OR 1.42) after revascularization in patients with ischemic heart failure and reduced ejection fraction.
Why the study?
Diabetes and heart failure are mutually reinforcing factors, but the treatment strategy and prognosis for patients with both conditions remain inconclusive.
Does coronary revascularization improve ejection fraction in patients with ischemic heart failure complicated with diabetes mellitus?
Does coronary revascularization improve ejection fraction in patients with ischemic heart failure complicated with diabetes mellitus?
Odds Ratio: 1.42 (95% CI 1.07–1.89)
p-value: p=0.014
Diabetes may be an indication for revascularization in patients with heart failure with reduced ejection fraction due to associated greater ejection fraction improvement.
May guide revascularization decisions in diabetic ischemic HFrEF; hypothesis-generating and requires prospective confirmation.
Diabetes and heart failure are mutually reinforcing factors. The treatment strategy and prognosis for patients with both diabetes and heart failure are inconclusive. This article reviews the current situation of ischemic heart failure complicated with diabetes, the pathophysiological relationship between diabetes and heart failure, and disease management. Especially, we highlight the latest result from CRISIS (Coronary Revascularization in Patients with Ischemic Heart Failure and Prevention of Sudden Cardiac Death) study, which finds that diabetes associates with greater ejection fraction improvement after revascularization in patients with reduced ejection fraction. This result implies the indication for revascularization in patients with heart failure who present with DM.
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Zhang et al. (2021) conducted a review in Ischemic Heart Failure (n=974). Diabetes Mellitus vs. Non-diabetic patients was evaluated on Greater ejection fraction (EF) improvement after revascularization (OR 1.42, 95% CI 1.07-1.89, p=0.014). Diabetes mellitus was independently associated with greater ejection fraction improvement (OR 1.42) after revascularization in patients with ischemic heart failure and reduced ejection fraction.
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