Why the study?
Patients with diabetes mellitus have a high prevalence of heart failure and poorer outcomes, with complex bidirectional pathophysiological interactions linking both conditions.
This review highlights the bidirectional relationship between heart failure and diabetes, emphasizing the use of SGLT2 inhibitors and metformin for glycemic control without hyperinsulinemia, and standard guideline-directed medical therapy for HF.
Patients with diabetes mellitus (DM) have a higher prevalence of heart failure (HF) than those without it. Approximately 40% of HF patients have DM, having poorer outcomes than those without DM. Myocardial ischemia caused by endothelial dysfunction, renal dysfunction, obesity, and impaired myocardial energetics is pathophysiology of DM-induced HF (DM-HF). Also, patients with HF show an increased risk for the onset of DM due to several mechanisms including insulin resistance. This review is focused on the epidemiology, pathogenic mechanism and treatment strategy of DM-HF.
No takes yet. Share an insight, caveat, or question.
Hae‐Young Lee (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: