Why the study?
Does heart failure increase the risk of developing diabetes mellitus in nondiabetic older adults?
Population
3,748 nondiabetic ambulatory older adults aged ≥65 years from the Cardiovascular Health Study
Comparison
Presence of heart failure at baseline vs Absence of heart failure at baseline
Design
Cohort
Follow-up
3 or 4 years
Key result
Baseline heart failure in older adults was significantly associated with worsening diabetes mellitus status over 3 to 4 years (OR 2.43; 95% CI 1.38-4.29; p=0.002).
Authors
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HF may raise DM risk in older adults; leaves open bidirectional causality and needs confirmation.
Cohort (n=3,748)
Does heart failure increase the risk of developing diabetes mellitus in nondiabetic older adults?
Odds Ratio: 2.43 (95% CI 1.38–4.29)
p-value: p=0.002
In older adults, the presence of heart failure more than doubles the risk of developing diabetes mellitus within 3 to 4 years, independent of other cardiovascular comorbidities.
Guglin et al. (2014) conducted a cohort in Nondiabetic (n=3,748). Heart failure vs. No heart failure was evaluated on Worsening DM status (OR 2.43, 95% CI 1.38-4.29, p=0.002). Baseline heart failure in older adults was significantly associated with worsening diabetes mellitus status over 3 to 4 years (OR 2.43; 95% CI 1.38-4.29; p=0.002).