Key result
Screening of 58,817 maternal donors of publicly banked umbilical cord blood in the United States identified 19 cases (0.032%) of confirmed Trypanosoma cruzi infection.
Why the study?
What is the prevalence of Trypanosoma cruzi in maternal donors of publicly banked umbilical cord blood in the US?
Cohort (n=58,817)
Yes
What is the prevalence of Trypanosoma cruzi in maternal donors of publicly banked umbilical cord blood in the US?
Screening of umbilical cord blood revealed a 0.04% prevalence of Trypanosoma cruzi, highlighting the need for targeted prenatal screening programs to prevent perinatal transmission of Chagas disease.
Supports targeted prenatal Chagas screening in the US; leaves open prospective validation of outcomes.
To assess patterns of Chagas disease, we reviewed results of screening umbilical cord blood from a US public cord blood bank during 2007-2014. Nineteen maternal donors tested positive for Trypanosoma cruzi parasites (0.04%). Because perinatal transmission of Chagas disease is associated with substantial illness, targeted prenatal programs should screen for this disease.
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Edwards et al. (2016) conducted a cohort in Chagas disease (n=58,817). Trypanosoma cruzi infection was evaluated on Confirmed Trypanosoma cruzi seroprevalence. Screening of 58,817 maternal donors of publicly banked umbilical cord blood in the United States identified 19 cases (0.032%) of confirmed Trypanosoma cruzi infection.
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