Key result
Higher maternal Trypanosoma cruzi parasitemia and density are linked to increased congenital infection risk.
Population
359 pregnant women in Yacuiba in southern Bolivia, of whom 147 (40.9%) were infected with Trypanosoma cruzi
Design
Cohort
Follow-up
through pregnancy and delivery
Authors
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Maternal parasitemia monitoring may inform congenital Chagas risk stratification in late pregnancy; leaves open whether reducing density prevents transmission.
Cohort (n=359)
Maternal Trypanosoma cruzi parasitemia density, particularly in the third trimester, is significantly correlated with the risk of congenital Chagas disease transmission.
Brutus et al. (2010) conducted a cohort in Chagas disease (n=359). Trypanosoma cruzi parasitemia vs. No parasitemia or lower parasite density was evaluated on Congenital infection. Maternal Trypanosoma cruzi parasitemia and parasite density were significantly correlated with the likelihood of congenital infection, with transmission risk increasing during the third trimester.
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