Key result
Domestic vector exposure in T. cruzi-infected women was associated with an increased risk of Chagas cardiomyopathy (OR 3.7; 95% CI 1.4-10.2) but a decreased risk of congenital transmission.
Why the study?
Does sustained domestic vector exposure increase the risk of Chagas cardiomyopathy and congenital transmission in T. cruzi-infected pregnant women?
Population
1,696 pregnant women presenting for delivery in two hospitals in Bolivia, of whom 456 were infected with…
Comparison
Sustained domestic vector exposure. vs No reported history of living in an infested…
Design
Cohort, Two cardiologists blinded to each other's reading evaluated each ECG
Follow-up
Infants followed at 1, 6, and 9 months of age
Authors
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May warrant cardiomyopathy surveillance in exposed women; leaves open vector control effects on congenital transmission.
Observational (n=1,696)
Does sustained domestic vector exposure increase the risk of Chagas cardiomyopathy and congenital transmission in T. cruzi-infected pregnant women?
Odds Ratio: 3.7 (95% CI 1.4–10.2)
Sustained vector exposure in T. cruzi-infected women increases the risk of Chagas cardiomyopathy but paradoxically decreases maternal parasitemia and the risk of congenital transmission.
Kaplinski et al. (2015) conducted an observational in Trypanosoma cruzi infection (Chagas disease) (n=1,696). Domestic vector exposure (living in infested houses) vs. No domestic vector exposure was evaluated on ECG abnormalities consistent with Chagas cardiomyopathy (OR 3.7, 95% CI 1.4-10.2). Domestic vector exposure in T. cruzi-infected women was associated with an increased risk of Chagas cardiomyopathy (OR 3.7; 95% CI 1.4-10.2) but a decreased risk of congenital transmission.
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