Key result
Higher triglycerides and remnant cholesterol were observationally and genetically associated with increased risk of aortic valve stenosis (genetic OR 1.51; 95% CI 1.22-1.86 for highest allele score).
Why the study?
To test whether higher levels of plasma triglycerides and remnant cholesterol are observationally and genetically associated with an increased risk of aortic valve stenosis.
Are higher levels of plasma triglycerides and remnant cholesterol associated with an increased risk of aortic valve stenosis in the general population?
Observational (n=108,559)
Are higher levels of plasma triglycerides and remnant cholesterol associated with an increased risk of aortic valve stenosis in the general population?
Odds Ratio: 1.51 (95% CI 1.22–1.86)
Higher plasma triglycerides and remnant cholesterol are both observationally and genetically associated with an increased risk of incident aortic valve stenosis.
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Higher triglycerides may raise aortic valve stenosis risk; hypothesis-generating for prevention trials.
Kaltoft et al. (2020) conducted an observational in Aortic valve stenosis (n=108,559). Higher plasma triglycerides and remnant cholesterol vs. Lower plasma triglycerides and remnant cholesterol was evaluated on Incident aortic valve stenosis (OR 1.51, 95% CI 1.22-1.86). Higher triglycerides and remnant cholesterol were observationally and genetically associated with increased risk of aortic valve stenosis (genetic OR 1.51; 95% CI 1.22-1.86 for highest allele score).
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