April 1, 2018The Journal of Cardiovascular Surgery
Initial clinical and hemodynamic results of a regional pulmonary thromboendarterectomy program
Key result
Pulmonary thromboendarterectomy improved mean pulmonary artery pressure from 45 to 24 mmHg and reduced NYHA class from 3.1 to 2.2, with an in-hospital mortality of 4.2%.
Why the study?
Does pulmonary thromboendarterectomy improve hemodynamics, right heart function, and clinical symptoms in patients with chronic thromboembolic pulmonary hypertension at a regional center?
Population
71 patients undergoing pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension at…
Comparison
Pulmonary thromboendarterectomy (PTE) vs Pre-operative baseline (no separate control group)
Design
Cohort
Follow-up
in-hospital / post-PTE
Authors
Discussion
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Implication
Supports regional PTE feasibility with hemodynamic and functional gains; leaves open durability versus national centers.
Study Design
Type
Observational (n=71)
Multicenter
No
Structured PICO
Does pulmonary thromboendarterectomy improve hemodynamics, right heart function, and clinical symptoms in patients with chronic thromboembolic pulmonary hypertension at a regional center?
P
Population
71 patients (mean age 56, 54% female) with chronic thromboembolic pulmonary hypertension who underwent pulmonary thromboendarterectomy at a regional center.
E
Exposure
Pulmonary thromboendarterectomy (PTE)
C
Comparator
Pre-operative baseline (no separate control group)
O
Outcome
Clinical, echocardiographic, and hemodynamic parameters (NYHA class, mPAP, cardiac index, PVR, RV:LV ratio, RV fractional area change) and in-hospital mortalitysurrogate
Main Result
Absolute Event Rate: 24% vs 45%
Pulmonary thromboendarterectomy performed at a regional center significantly improves hemodynamics, right heart function, and symptoms in patients with CTEPH, with low in-hospital mortality.
Cite This Study
Raza et al. (2018) conducted an observational in Chronic thromboembolic pulmonary hypertension (CTEPH) (n=71). Pulmonary thromboendarterectomy (PTE) vs. Pre-PTE baseline was evaluated on Mean pulmonary artery pressure (mmHg). Pulmonary thromboendarterectomy improved mean pulmonary artery pressure from 45 to 24 mmHg and reduced NYHA class from 3.1 to 2.2, with an in-hospital mortality of 4.2%.