Key result
In patients with CTEPH, TAPSE paradoxically decreased from 18±6 to 10±3 mm early after pulmonary thromboendarterectomy (P<.0001), losing its preoperative correlation with pulmonary vascular resistance.
Why the study?
Does pulmonary thromboendarterectomy alter TAPSE and RVFAC, and do these echocardiographic parameters correlate with pulmonary vascular resistance in patients with CTEPH?
Cohort (n=67)
Does pulmonary thromboendarterectomy alter TAPSE and RVFAC, and do these echocardiographic parameters correlate with pulmonary vascular resistance in patients with CTEPH?
Absolute Event Rate: 10% vs 18%
p-value: p=<.0001
TAPSE paradoxically decreases early after pulmonary thromboendarterectomy despite marked improvements in afterload, indicating it cannot be used as an early echocardiographic marker for surgical success.
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TAPSE/RVFAC changes post-PTE associate with hemodynamics in CTEPH; leaves open prognostic utility and practice adoption.
Wong et al. (2016) conducted a cohort in Chronic thromboembolic pulmonary hypertension (CTEPH) (n=67). Pulmonary thromboendarterectomy (PTE) vs. Preoperative baseline was evaluated on Tricuspid annular plane systolic excursion (TAPSE) (p=<.0001). In patients with CTEPH, TAPSE paradoxically decreased from 18±6 to 10±3 mm early after pulmonary thromboendarterectomy (P<.0001), losing its preoperative correlation with pulmonary vascular resistance.
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