Key result
During myocardial ischaemia, cardiac sympathetic afferents are activated by adenosine released from the ischaemic myocardium via adenosine A1 receptors, mediating sympathoexcitatory responses and angina.
Design
Review
Authors
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Reflex responses to ischaemia may inform acute management strategies; RCT confirms differential vagal versus sympathetic afferent effects.
This review highlights the mechanistic role of adenosine A1 receptors in activating cardiac sympathetic afferents during myocardial ischemia, which contributes to autonomic reflex changes and the sensation of angina.
Thames et al. (1996) conducted a review in Myocardial ischaemia. Adenosine was evaluated. During myocardial ischaemia, cardiac sympathetic afferents are activated by adenosine released from the ischaemic myocardium via adenosine A1 receptors, mediating sympathoexcitatory responses and angina.
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