Key result
High-sensitivity C-reactive protein levels independently correlated with increased carotid intima-media thickness (r = 0.251; p = 0.03), independent of insulin sensitivity.
Why the study?
Is subclinical chronic inflammation or insulin resistance associated with early carotid atherosclerosis in overweight non-diabetic individuals?
Cross-Sectional (n=81)
Is subclinical chronic inflammation or insulin resistance associated with early carotid atherosclerosis in overweight non-diabetic individuals?
Effect estimate: r = 0.251
p-value: p=0.03
In young, overweight, non-diabetic individuals, early carotid atherosclerosis is associated with subclinical chronic inflammation (hsCRP) rather than insulin resistance.
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Whether ISI or inflammation primarily drives early arterial thickening in overweight youth remains unresolved; leaves open the dominant mechanism.
Balletshofer et al. (2005) conducted a cross-sectional in Overweight (n=81). High-sensitivity C-reactive protein (hsCRP) levels was evaluated on Intima-media thickness (IMT) at the common carotid artery (r = 0.251, p=0.03). High-sensitivity C-reactive protein levels independently correlated with increased carotid intima-media thickness (r = 0.251; p = 0.03), independent of insulin sensitivity.
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