Key result
Lower insulin sensitivity was associated with higher carotid intima-media thickness in men (P<0.05), while in women, higher thickness was associated with fasting plasma glucose (P<0.0005).
Why the study?
Is insulin sensitivity independently associated with early carotid atherosclerosis (CCA-IMT) in healthy adults?
Population
1,180 healthy adults, mean age 44 ± 8 years, free of conditions known to affect carotid wall.
Comparison
Insulin sensitivity and metabolic correlates vs Higher vs lower tertiles of insulin sensitivity…
Design
Cohort
Follow-up
3 years
Authors
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May inform sex-specific risk assessment in primary prevention; leaves open causal roles and need for prospective trials.
Cohort (n=1,180)
Yes
Is insulin sensitivity independently associated with early carotid atherosclerosis (CCA-IMT) in healthy adults?
p-value: p=<0.05
Insulin resistance is associated with early carotid atherosclerosis in healthy men, mediated by free fatty acids and adipocytokines, whereas fasting glucose is the primary determinant in women.
Kozàkovà et al. (2013) conducted a cohort in Healthy (n=1,180). Insulin sensitivity vs. Higher insulin sensitivity was evaluated on Baseline intima-media thickness in the common carotid artery (CCA-IMT) (p=<0.05). Lower insulin sensitivity was associated with higher carotid intima-media thickness in men (P<0.05), while in women, higher thickness was associated with fasting plasma glucose (P<0.0005).
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