Key result
Lower insulin secretion was associated with increased carotid intima-media thickness in healthy nondiabetic individuals, independent of insulin sensitivity (Ptrend=0.004).
Why the study?
Is insulin secretion associated with carotid intima-media thickness independently of insulin resistance in healthy individuals?
Population
1,044 healthy individuals, mean age 44 ± 8 years, free of diabetes, hypertension, dyslipidemia, and other…
Design
Cross-sectional
Authors
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Supports beta-cell dysfunction in early atherosclerosis; leaves open causal role and need for prospective trials.
Cohort (n=1,044)
Yes
Is insulin secretion associated with carotid intima-media thickness independently of insulin resistance in healthy individuals?
Effect estimate: Spearman partial correlation -0.09
p-value: p=<0.05
Lower insulin secretion is associated with early carotid atherosclerosis in healthy, nondiabetic individuals, independent of insulin sensitivity.
Roussel et al. (2016) conducted a cohort in Healthy individuals (n=1,044). Insulin secretion vs. Higher insulin secretion was evaluated on Intima-media thickness (IMT) in the common carotid artery (Spearman partial correlation -0.09, p=<0.05). Lower insulin secretion was associated with increased carotid intima-media thickness in healthy nondiabetic individuals, independent of insulin sensitivity (Ptrend=0.004).
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