February 1, 1997Journal of Hypertension

Association between hyperinsulinemia and intima-media thickness of the carotid artery in normotensive men

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Why the study?

Is hyperinsulinemia associated with increased carotid intima-media thickness in normotensive, nondiabetic men?

Population

164 normotensive, nondiabetic male transport workers aged ≥40 years, not taking hyperlipidemia medications…

Design

Cross-sectional

Authors

KFKoji FujiiTokushima Red Cross Hospital IAIsao AbeAjinomoto (United States)YOYusuke OhyaPreventive Cardiology

Discussion

Member takes

Implication

Should not yet change practice in normotensive nondiabetic men; leaves open causality and need for prospective studies.

Structured PICO

Is hyperinsulinemia associated with increased carotid intima-media thickness in normotensive, nondiabetic men?

Population

164 normotensive, nondiabetic male transport workers aged ≥40 years, not taking hyperlipidemia medications, mean age 52 ± 5 years.

Intervention

Hyperinsulinemia assessed by 75 g oral glucose-tolerance test (OGTT) markers (sum of insulin values [sigmaIRI] and ratio of sum of insulin to blood glucose [sigmaIRI/sigmaBG])

Outcome

Intima-media thickness (IMT) of the carotid artery measured by B-mode ultrasonographysurrogate

Hyperinsulinemia is independently associated with early atherosclerosis (increased carotid IMT) in normotensive, nondiabetic men.

Cite This Study

Fujii et al. (1997) studied this question.

synapsesocial.com/papers/6a711af8f44fa9f079dee055 https://doi.org/10.1097/00004872-199715020-00007

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Association between hyperinsulinemia and intima-media thickness of the carotid artery in normotensive men

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Association between hyperinsulinemia and intima-media thickness of the carotid artery in normotensive men

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider