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October 30, 2012European Journal of Preventive Cardiology

Efficacy of a long-term secondary prevention programme following inpatient cardiovascular rehabilitation on risk and health-related quality of life in a low-education cohort: a randomized controlled study

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Key result

A long-term secondary prevention programme reduced average intima-media thickness by 0.03 mm compared to a 0.04 mm increase with usual care (p=0.014) over 3 years in low-education CAD patients.

Why the study?

Does a long-term secondary prevention program with an additional rehabilitation session and telephone reminders improve cardiovascular risk and health-related quality of life in middle-aged CAD patients with low education?

Population

600 middle-aged patients with coronary artery disease of low educational level. Average age nearly 50 years…

Comparison

Long-term secondary prevention program… vs Usual care, consisting of only the initial…

Design

RCT

Follow-up

36 months

Authors

WMWolfgang Mayer-BergerDSDušan SimićJMJawad Mahmoodzad

Discussion

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Overview

Supports exploration of education-tailored prevention in low-education CAD; leaves open efficacy versus usual care pending randomized data.

Study Design

Type

RCT (n=600)

Structured PICO

Does a long-term secondary prevention program with an additional rehabilitation session and telephone reminders improve cardiovascular risk and health-related quality of life in middle-aged CAD patients with low education?

P
Population
600 middle-aged (≤58 years) patients with coronary artery disease and low educational level, followed for 36 months.
I
Intervention
Long-term secondary prevention program consisting of a 3-week comprehensive cardiovascular inpatient rehabilitation program at baseline, one further rehabilitation session in hospital after 6 months, and regular telephone reminders over a period of 36 months.
C
Comparator
Usual care, consisting of only the initial 3-week comprehensive cardiovascular inpatient rehabilitation program at baseline.
O
Outcome
Cardiovascular risk (evaluated by PROCAM score and intima-media thickness [IMT] at the common carotid artery) and health-related quality of life (assessed with EUROQOL and HADS) at 3 years.

Main Result

Absolute Event Rate: -0.03% vs 0.04%

p-value: p=0.014

A long-term secondary prevention program incorporating an additional rehab session and telephone reminders over 3 years significantly improved carotid intima-media thickness and quality of life in middle-aged, low-education patients with CAD.

Cite This Study

Mayer-Berger et al. (2012) conducted an RCT in Coronary artery disease (CAD) (n=600). Long-term secondary prevention programme vs. Usual care was evaluated on Change in intima-media thickness (IMT) (p=0.014). A long-term secondary prevention programme reduced average intima-media thickness by 0.03 mm compared to a 0.04 mm increase with usual care (p=0.014) over 3 years in low-education CAD patients.

synapsesocial.com/papers/6a61e7635d85cff801c933f8https://doi.org/10.1177/2047487312465526
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac risk factors, medication, and recurrent clinical events after acute coronary disease. A prospective cohort study2001 · 157 citations
  2. 2One-year follow-up of a therapeutic lifestyle intervention targeting cardiovascular disease risk2007 · 148 citations
  3. 3Outcomes of cardiac rehabilitation with versus without a follow-up intervention rendered by telephone (Luebeck follow-up trial): overall and gender-specific effects2006 · 94 citations
  4. 4The Effect of a Telephone Counseling Intervention on Self-Rated Health of Cardiac Patients2005 · 56 citations
  5. 5EUROASPIRE: A European Society of Cardiology survey of secondary prevention of coronary heart disease: Principal results1997 · 532 citations