Key result
A higher lipid accumulation product index was independently associated with an increased risk of elevated arterial stiffness in Chinese adults with hypertension (OR 1.24).
Why the study?
Previous studies evaluating the relation between LAP index and baPWV have yielded inconsistent results.
Is the lipid accumulation product (LAP) index associated with arterial stiffness in Chinese adults with hypertension?
Cross-Sectional (n=4,926)
Is the lipid accumulation product (LAP) index associated with arterial stiffness in Chinese adults with hypertension?
Odds Ratio: 1.24 (95% CI 1.09–1.4)
p-value: p=<0.001
The lipid accumulation product index is positively and linearly associated with arterial stiffness in Chinese adults with hypertension.
Supports LAP as stiffness marker in hypertension; hypothesis-generating and requires prospective validation before any clinical use.
Background: The relation of LAP index with baPWV have been evaluated in several previous studies and yield inconsistent results. The aim of the study was to investigate the association between the lipid accumulation product (LAP) index and arterial stiffness in the Chinese population with hypertension. Methods: We conducted a cross-sectional analysis in 4926 participants chinese population with hypertension (aged 64.42 ± 9.44years). The LAP was developed from population-based frequency plots of adult waist circumferences and circulating triglyceride concentrations. Arterial stifness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results: Multivariate linear regression analyses showed that LAP index was independently and positively associated with baPWV ( β , 25.06 cm/s (95% confdence interval [CI]: 10.91, 39.22 cm/s). Consistently, Multiple logistic analyses showed a positive association between LAP index risk of elevated baPWV (>75th percentile) (odds ratio [OR], 1.24; 95% CI 1.09, 1.40). A restricted cubic spline showed that the significant linear association existed between LAP index and baPWV. Similar results were found in various subgroups. Conclusion: LAP is a signifcant positive associated with with baPWV and elevated baPWV in Chinese hypertensive adults.
No takes yet. Share an insight, caveat, or question.
Shi et al. (2021) conducted a cross-sectional in Hypertension (n=4,926). Lipid accumulation product (LAP) index vs. Lower LAP index was evaluated on Elevated brachial-ankle pulse wave velocity (>75th percentile) (OR 1.24, 95% CI 1.09, 1.40, p=<0.001). A higher lipid accumulation product index was independently associated with an increased risk of elevated arterial stiffness in Chinese adults with hypertension (OR 1.24).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: