Key result
In Chinese patients with type 2 diabetes, each unit increase in the natural logarithm of the lipid accumulation product index was associated with an increased risk of elevated arterial stiffness (OR 1.3).
Why the study?
Although lipid accumulation products predict arterial stiffness in hypertensive patients, little research exists on using the index to identify early atherosclerosis in patients with type 2 diabetes mellitus.
Does the lipid accumulation product (LAP) index correlate with arterial stiffness in Chinese patients with type 2 diabetes?
Cross-Sectional (n=1,471)
No
Does the lipid accumulation product (LAP) index correlate with arterial stiffness in Chinese patients with type 2 diabetes?
Odds Ratio: 1.3 (95% CI 1–1.8)
In Chinese patients with type 2 diabetes, the lipid accumulation product index is independently and positively correlated with arterial stiffness, suggesting its utility as a simple marker for early atherosclerosis.
Background: Many studies have confirmed that lipid accumulation products (LAP) predict arterial stiffness (AS) in hypertensive patients. But there is little research on the use of LAP in identifying early atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to determine the relationship between the LAP index and brachial-ankle pulse wave velocity (baPWV) in Chinese patients with T2DM. Methods: A total of 1471 Chinese participants with T2DM, ranging in age from 18 to 80, were included in this cross-sectional study. BaPWV measurements were used to calculate the AS. A baPWV greater than the 75th percentile (1700 cm/s) was defined as indicating increased AS. The LAP index was calculated from the combination of waist circumference (WC) and triglycerides (TG). Results: According to the quartiles of the LAP index, baPWV tended to increase after adjusting for sex and age. Multiple linear regression analysis showed that the beta coefficient (β) of baPWV increased by 31.0 cm/s for each unit of lnLAP that was increased, and the 95% confidence interval (CI) was (6.5, 55.5) cm/s. In multivariate logistic regression analyses, after fully adjusting for confounders, the risk of elevated baPWV increased with each unit increase in lnLAP, with an odds ratio (OR) of 1.3 (95% CI: 1.0, 1.8). According to the generalized additive model (GAM), we found that lnLAP was positively correlated with baPWV and baPWV elevation. The results were the same for males and females. Subgroup analyses showed that the positive correlation between lnLAP and elevated baPWV did not interact across all subgroups. Conclusions: In Chinese patients with T2DM, LAP was strongly and positively correlated with baPWV and elevated baPWV.
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Mao et al. (2023) conducted a cross-sectional in Type 2 diabetes mellitus (n=1,471). Lipid accumulation product (LAP) index vs. Lower LAP index was evaluated on Elevated brachial-ankle pulse wave velocity (baPWV > 1700 cm/s) (OR 1.3, 95% CI 1.0-1.8). In Chinese patients with type 2 diabetes, each unit increase in the natural logarithm of the lipid accumulation product index was associated with an increased risk of elevated arterial stiffness (OR 1.3).
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