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This article provides a comprehensive review of renin, including its gene structure, biosynthesis, release regulation, and genetic studies in humans and transgenic models.
This article provides a comprehensive review of the structure, regulation, biosynthesis, and genetics of renin, including insights from transgenic and knockout animal models.
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Synthesizes renin genetics and regulation; leaves open clinical translation of animal model insights.
The sections in this article are: The Renin Paper A blood pressure‐raising substance is formed in the kidneys and passed into the blood Time course of the pressure elevation following injection of renin Analysis of the mechanism underlying the pressure rise Renin Release Regulation Renin Gene: Structure and Control Background Renin Gene Structure Renin Promoter Structure Renin Promoter Control Transcription Factors Renin Messenger RNA Synthesis and Activation Biosynthesis of Prorenin Processing of Prorenin Structure of Renin Binding Protein(s) of Renin Genetic Studies Studies in Rats Studies in Humans Transgenic Mice and Rats Human Gene in Mice Renin Promoter–Simian Virus 40 T Antigen Transgenic Mice Human Promoter Transgenic Mice Ren‐2 Hypertensive Transgenic Rats Model of Malignant Hypertension Renin and Angiotensinogen Transgenic Mice and Rats Knockouts Summary and Challenges
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Brian J. Morris (1999) reported a review. Renin was evaluated. This article provides a comprehensive review of renin, including its gene structure, biosynthesis, release regulation, and genetic studies in humans and transgenic models.
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