Key result
Chronic kidney disease amplified the independent association between aortic stiffness and interstitial myocardial fibrosis (B 0.2 vs 0.1; p<0.01).
Why the study?
Patients with CKD have high cardiovascular morbidity and mortality, prompting investigation into the relationship between aortic stiffness, myocardial fibrosis, left ventricular remodeling, and CKD severity.
Population
276 consecutive CKD patients and 242 age-gender matched controls
Comparison
CKD patients vs age-gender matched controls with no known kidney disease
Design
Observational study
Authors
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CKD may strengthen aortic stiffness-fibrosis links on imaging; extends observational data but leaves open causal or therapeutic implications.
Observational (n=518)
Effect estimate: B 0.2 (CKD) vs 0.1 (non-CKD) (95% CI 0.15-0.25 (CKD) vs 0.06-0.15 (non-CKD))
p-value: p=<0.01
Aortic stiffness and interstitial myocardial fibrosis are interrelated, and this association is accelerated in patients with chronic kidney disease.
Chen et al. (2019) conducted an observational in Chronic kidney disease (n=518). Chronic kidney disease vs. Age-gender matched controls with no known kidney disease was evaluated on Association between aortic stiffness (PWV) and interstitial myocardial fibrosis (native T1) (B 0.2 (CKD) vs 0.1 (non-CKD), 95% CI 0.15-0.25 (CKD) vs 0.06-0.15 (non-CKD), p=<0.01). Chronic kidney disease amplified the independent association between aortic stiffness and interstitial myocardial fibrosis (B 0.2 vs 0.1; p<0.01).
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