Key result
Chronic kidney disease was associated with significantly lower flow-mediated dilatation compared to controls (9.1% vs 18.3%, p<0.001), which improved to 15.7% three months after renal transplantation.
Why the study?
Does renal transplantation improve endothelial dysfunction in patients with chronic kidney disease?
Population
108 Asian Indian patients with chronic kidney disease, 60 of whom underwent renal transplantation, and…
Comparison
Renal transplantation vs Healthy controls and pre-transplantation state
Design
Cohort
Follow-up
3 months
Authors
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Endothelial dysfunction assessment may refine CV risk stratification in CKD; leaves open whether transplantation restores function.
Observational (n=108)
Does renal transplantation improve endothelial dysfunction in patients with chronic kidney disease?
Absolute Event Rate: 9.1% vs 18.3%
p-value: p=<0.001
Renal transplantation significantly improves endothelium-dependent vasodilation in patients with chronic kidney disease within three months.
Sharma et al. (2014) conducted an observational in Chronic kidney disease (n=108). Chronic kidney disease vs. Healthy controls was evaluated on Flow-mediated dilatation (FMD) (p=<0.001). Chronic kidney disease was associated with significantly lower flow-mediated dilatation compared to controls (9.1% vs 18.3%, p<0.001), which improved to 15.7% three months after renal transplantation.
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