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January 1, 2002˜The œNephron journals/Nephron journals

Impairment of Vascular Responses to Reactive Hyperemia and Nitric Oxide in Chronic Renal Failure

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Why the study?

Is endothelial function and response to nitric oxide impaired in patients with chronic renal failure compared to healthy individuals?

Population

Healthy individuals and patients with chronic renal failure with or without maintenance hemodialysis

Design

Cross-sectional

Authors

TNTakeshi NakanishiYIYuki IshigamiYOYoshinaga Otaki

Discussion

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Overview

Endothelial dysfunction evident early in chronic renal failure; hypothesis-generating for vascular-targeted interventions before dialysis.

Key Points

  • This research examines how chronic renal failure affects endothelial function and vascular responses to nitric oxide.
  • Measured flow-mediated vasodilation (%FMD) and endothelium-independent vasodilation (%NTG) in healthy individuals and chronic renal failure patients.
  • Participants included those undergoing hemodialysis (HD) and those who were not (ND).
  • Analyzed correlations between plasma concentrations of homocysteine, cysteine, and nitric oxide metabolites with endothelial function measures.
  • Both ND and HD patients showed significantly elevated levels of plasma homocysteine, cysteine, and nitric oxide metabolites.
  • Reactive hyperemia, %FMD, and %NTG were similarly reduced in both ND and HD groups.
  • Multivariate analysis indicated a direct correlation between nitric oxide metabolites and both %FMD and %NTG, while glutathione only correlated with %NTG.

Structured PICO

Is endothelial function and response to nitric oxide impaired in patients with chronic renal failure compared to healthy individuals?

P
Population
Healthy individuals and patients with chronic renal failure with or without maintenance hemodialysis
C
Comparator
Healthy individuals
O
Outcome
Endothelial function measured by flow-mediated vasodilation (%FMD) during reactive hyperemia and endothelium-independent vasodilation (%NTG) after sublingual glyceryl trinitrate spray (0.3 mg)surrogate

Chronic renal failure impairs endothelial function and vascular response to nitric oxide even before the initiation of maintenance hemodialysis.

Cite This Study

Nakanishi et al. (2002) studied this question.

synapsesocial.com/papers/6a2066b4d1cd0ea0c19cd7d6https://doi.org/10.1159/000064078
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence In Vivo Showing Increase of Baseline Nitric Oxide Generation and Impairment of Endothelium-Dependent Vasodilation in Normotensive Patients on Chronic Hemodialysis2000 · 67 citations
  2. 2Impaired endothelium‐dependent vasodilatation in renal failure in humans2001 · 104 citations
  3. 3Mechanisms of Endothelial Dysfunction in Resistance Arteries from Patients with End-Stage Renal Disease2012 · 39 citations
  4. 4Effect of N-Acetylcysteine on Endothelial Dysfunction in Dialysis Patients2007 · 38 citations
  5. 5Assessment of endothelial dysfunction in Asian Indian patients with chronic kidney disease and changes following renal transplantation2014 · 22 citations