Key result
A single hemodialysis session is linked to an ~18% decrease in NO2- and increased malondialdehyde.
Why the study?
Does a single hemodialysis session affect endothelial dysfunction and oxidative stress in patients with end-stage renal disease?
Population
20 chronic hemodialysis patients with end-stage renal disease. 65% had chronic glomerulonephritis.
Comparison
A single hemodialysis (HD) session vs Baseline (before the hemodialysis session)
Design
Cohort
Follow-up
Single hemodialysis session
Authors
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Acute oxidative changes during hemodialysis may signal endothelial risk in ESRD; leaves open long-term vascular implications.
Observational (n=20)
Does a single hemodialysis session affect endothelial dysfunction and oxidative stress in patients with end-stage renal disease?
Effect estimate: 18.4% decrease
p-value: p=<0.001
A single hemodialysis session in ESRD patients acutely increases oxidative stress and decreases nitric oxide metabolites, indicating potential endothelial damage.
Susla et al. (2017) conducted an observational in End-stage renal disease (n=20). Single hemodialysis session vs. Before hemodialysis session (baseline) was evaluated on Plasma content of nitrite (NO2-) (18.4% decrease, p=<0.001). A single hemodialysis session in patients with end-stage renal disease significantly decreased NO2- content by 18.4% (p<0.001) and increased malondialdehyde by 10.5% (p=0.007).
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