Key result
A single hemodialysis session is linked to a ~63% improvement in endothelium-dependent venodilation in ESRD.
Why the study?
The acute effect of hemodialysis on endothelial venous function and oxidative stress in end-stage renal disease patients was not well defined.
Does a hemodialysis session improve endothelial venous function in patients with end-stage renal disease?
Population
9 ESRD patients on hemodialysis and 10 healthy controls matched for age and gender
Comparison
Endothelial function before and after a hemodialysis session and versus healthy controls
Design
Observational study using dorsal hand vein technique and oxidative stress markers
Follow-up
Immediately before and after a hemodialysis session
Authors
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Acute endothelial improvement after one session should not alter practice; leaves open long-term vascular benefits in ESRD.
Observational (n=19)
Does a hemodialysis session improve endothelial venous function in patients with end-stage renal disease?
Absolute Event Rate: 106.6% vs 65.6%
p-value: p=0.045
A single hemodialysis session acutely improves endothelial venous function in patients with end-stage renal disease, which correlates with changes in antioxidant capacity.
Silva et al. (2008) conducted an observational in End-stage renal disease (ESRD) (n=19). Hemodialysis session vs. Before hemodialysis was evaluated on Endothelium-dependent venodilation (EDV) (p=0.045). A single hemodialysis session significantly improved endothelium-dependent venodilation in patients with end-stage renal disease (106.6 vs 65.6 before dialysis; P=0.045).
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