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September 1, 2001Nephrology Dialysis Transplantation

Dialysis improves endothelial function in humans

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Why the study?

Does a single episode of haemodialysis improve endothelial function compared to automated peritoneal dialysis in subjects with end-stage renal failure?

Population

30 subjects with end-stage renal failure undergoing haemodialysis or automated peritoneal dialysis.

Comparison

Single episode of haemodialysis vs Single episode of automated peritoneal dialysis

Design

Cohort

Follow-up

24 hours

Authors

JCJenny CrossADAnn E. DonaldPVPatrick Vallance

Discussion

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Overview

Single haemodialysis session was associated with acute endothelial improvement; hypothesis-generating for modality effects and requires randomized confirmation.

Structured PICO

Does a single episode of haemodialysis improve endothelial function compared to automated peritoneal dialysis in subjects with end-stage renal failure?

P
Population
30 subjects with end-stage renal failure undergoing haemodialysis (n=16) or automated peritoneal dialysis (n=14).
I
Intervention
Single episode of haemodialysis
C
Comparator
Single episode of automated peritoneal dialysis
O
Outcome
Endothelial function determined by flow-mediated dilatation of the brachial artery before and after a single dialysis treatmentsurrogate

A single session of hemodialysis, but not peritoneal dialysis, acutely improves endothelial function in patients with end-stage renal disease, likely by clearing dialyzable endothelial toxins.

Cite This Study

Cross et al. (2001) studied this question.

synapsesocial.com/papers/6a87a24fefc8d8a4433e9263https://doi.org/10.1093/ndt/16.9.1823
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodialysis Impairs Endothelial Function via Oxidative Stress2000 · 232 citations
  2. 2Endothelium-dependent vasodilatation is impaired in peritoneal dialysis patients1998 · 126 citations
  3. 3Effect of captopril and enalapril on endothelial function in hypertensive patients.1994 · 184 citations
  4. 4Effect of Treatment on Flow-Dependent Vasodilation of the Brachial Artery in Essential Hypertension1999 · 100 citations
  5. 5Demonstration of Rapid Onset Vascular Endothelial Dysfunction After Hyperhomocysteinemia1999 · 434 citations