Key result
Normotensive patients on chronic hemodialysis showed impaired endothelium-dependent vasodilation to acetylcholine (P=0.002) and increased baseline nitric oxide generation compared to controls.
Why the study?
Do normotensive patients on chronic hemodialysis have impaired endothelium-dependent vasodilation and altered nitric oxide generation compared to matched controls?
Case-Control (n=22)
Do normotensive patients on chronic hemodialysis have impaired endothelium-dependent vasodilation and altered nitric oxide generation compared to matched controls?
p-value: p=0.002
Normotensive patients on chronic hemodialysis exhibit impaired endothelium-dependent vasodilation and reduced capacity of the NO system to regulate vascular tone, despite increased baseline NO generation.
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Impaired endothelial NO vasodilation in normotensive HD patients should not yet change practice; leaves open causal role in uremic vascular risk.
Passauer et al. (2000) conducted a case-control in Chronic hemodialysis (n=22). Chronic hemodialysis vs. Matched control subjects was evaluated on Forearm blood flow response to acetylcholine (endothelium-dependent vasodilation) (p=0.002). Normotensive patients on chronic hemodialysis showed impaired endothelium-dependent vasodilation to acetylcholine (P=0.002) and increased baseline nitric oxide generation compared to controls.
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