Key result
Chronic hypotension during hemodialysis is linked to ~99% higher plasma nitrite and nitrate levels.
Why the study?
A subset of long-term hemodialysis patients have sustained hypotension, and the role of nitric oxide in this condition was unclear.
Are plasma levels of nitric oxide metabolites elevated in hemodialysis patients with sustained hypotension compared to normotensive controls?
Comparison
Hypotensive vs normotensive patients on hemodialysis
Design
Case-control study
Authors
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May warrant NO pathway evaluation in hypotensive hemodialysis; leaves open causal role and therapeutic utility.
Case-Control (n=25)
Are plasma levels of nitric oxide metabolites elevated in hemodialysis patients with sustained hypotension compared to normotensive controls?
Absolute Event Rate: 72.49% vs 36.42%
p-value: p=< 0.05
Enhanced nitric oxide production may contribute to chronic hypotension in a subset of patients on long-term hemodialysis.
Lin et al. (1996) conducted a case-control in Long-term hemodialysis (n=25). Sustained hypotension vs. Normotension was evaluated on Plasma levels of nitrite and nitrate (p=< 0.05). Chronic hypotensive patients on hemodialysis had significantly higher plasma nitrite and nitrate levels compared to normotensive controls (72.49 vs 36.42 mumol/L, p < 0.05).
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