Key result
L-NMMA prevents mean blood pressure drops during hemodialysis in dogs with renal dysfunction.
Why the study?
The role of nitric oxide in hemodialysis-related hypotension in renal dysfunction was unclear.
Does L-NMMA prevent hemodialysis-related hypotension in a dog model of renal dysfunction?
Does L-NMMA prevent hemodialysis-related hypotension in a dog model of renal dysfunction?
Nitric oxide synthase inhibition with L-NMMA prevents hemodialysis-induced hypotension in an experimental dog model of renal dysfunction.
NO contributes to HD hypotension in this canine model; L-NMMA prevents BP fall but leaves open human relevance and NOx utility.
To clarify the role of nitric oxide (NO) in hemodialysis (HD)-related hypotension, the relationship between plasma NO metabolites (NOx) and blood pressure changes, and the effect of N(G)-monomethyl-L-arginine (L-NMMA), a NO synthase inhibitor, on changes in blood pressure were evaluated in an experimental renal dysfunctional dog model. In order to create a renal dysfunction model, gentamicin was administered to male beagles in which 7 of 8 renal artery branches had been ligated. Normal renal functional and dysfunctional dogs underwent 3 hr of HD per day for 3 days. HD induced a transient decrease in mean blood pressure in the normal renal functional dogs. In renal dysfunctional dogs, a continuous hypotension occurred with a gradual increase in the plasma NOx concentration during HD. Although L-NMMA prevented the fall in blood pressure, it did not significantly change the plasma NOx concentration during HD. These results suggest that NO contributes to HD-related hypotension in renal dysfunctional dogs but the plasma NOx concentration does not reflect the change in blood pressure.
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Komeno et al. (2004) studied Hemodialysis-related hypotension (n=12). L-NMMA vs. Vehicle (physiological saline) was evaluated on Mean blood pressure (MBP) during hemodialysis (p=<0.05). Infusion of the nitric oxide synthase inhibitor L-NMMA significantly prevented the fall in mean blood pressure during hemodialysis in a dog model of renal dysfunction.
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