Key result
Failed renal transplant patients restarting hemodialysis had significantly lower coronary flow reserve compared to never-transplanted patients (1.60 vs 1.75, p=0.028).
Why the study?
Does a failed renal transplant worsen endothelial dysfunction in hemodialysis patients compared to those never transplanted?
Population
83 hemodialysis patients, including 40 who were never transplanted and 43 with failed renal transplants…
Comparison
Failed renal transplant restarting hemodialysis vs Hemodialysis without prior transplantation (nHD)
Design
Cross-sectional
Authors
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Associated with worse endothelial dysfunction in failed-transplant hemodialysis patients; leaves open causal impact of transplant failure versus confounding.
Cross-Sectional (n=83)
Does a failed renal transplant worsen endothelial dysfunction in hemodialysis patients compared to those never transplanted?
Absolute Event Rate: 1.6% vs 1.75%
p-value: p=0.028
Hemodialysis patients with failed renal transplants exhibit more prominent endothelial dysfunction and inflammation compared to those who were never transplanted.
Görgülü et al. (2009) conducted a cross-sectional in Hemodialysis (n=83). Failed renal transplant vs. Never transplanted was evaluated on Coronary flow reserve (CFR) (p=0.028). Failed renal transplant patients restarting hemodialysis had significantly lower coronary flow reserve compared to never-transplanted patients (1.60 vs 1.75, p=0.028).
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