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June 1, 2001Nephrology Dialysis TransplantationOpen Access

Endothelial dysfunction in chronic renal failure: roles of lipoprotein oxidation and pro‐inflammatory cytokines

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Why the study?

Is vascular endothelial dysfunction in chronic renal failure associated with LDL oxidation or pro-inflammatory cytokines?

Population

87 participants including 23 dialysed chronic renal failure patients, 16 non-dialysed CRF patients, 28…

Design

Cross-sectional

Authors

LDL G DownsJVJ G VictoryJDJeremy Dwight

Discussion

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Overview

Supports inflammation over LDL oxidation in CRF endothelial dysfunction; hypothesis-generating, prospective studies needed before clinical consideration.

Structured PICO

Is vascular endothelial dysfunction in chronic renal failure associated with LDL oxidation or pro-inflammatory cytokines?

P
Population
87 participants including 23 dialysed chronic renal failure (CRF) patients, 16 non-dialysed CRF patients, 28 healthy controls, and 20 patients with stable angina and normal renal function.
C
Comparator
Healthy controls and patients with stable angina and normal renal function
O
Outcome
Vascular endothelial dysfunction (measured by forearm flow-mediated vasodilatation), indices of LDL oxidation, and markers of inflammatory activitysurrogate

Endothelial dysfunction in chronic renal failure appears to be driven by a chronic inflammatory state rather than LDL oxidation.

Cite This Study

Downs et al. (2001) studied this question.

synapsesocial.com/papers/6a961c8dc278dbfca3d1bc4chttps://doi.org/10.1093/ndt/16.6.1189
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial function, CRP and oxidative stress in chronic kidney disease2005 · 98 citations
  2. 2Endothelial dysfunction and inflammation—is there a link?2001 · 136 citations
  3. 3The Role of Oxidative Stress–Altered Lipoprotein Structure and Function and Microinflammation on Cardiovascular Risk in Patients with Minor Renal Dysfunction2004 · 184 citations
  4. 4Impairment of Vascular Responses to Reactive Hyperemia and Nitric Oxide in Chronic Renal Failure2002 · 18 citations
  5. 5Impaired endothelium‐dependent vasodilatation in renal failure in humans2001 · 104 citations