Normotensive patients with mild heart failure had significantly higher plasma ADMA concentrations (4.18 vs 2.38 µmol/L, P<0.01) and reduced effective renal plasma flow compared to healthy controls.
Case-Control (n=24)
Are plasma ADMA concentrations increased and related to reduced renal perfusion in normotensive patients with mild heart failure compared to healthy controls?
In normotensive patients with mild heart failure, elevated plasma ADMA concentrations are associated with reduced renal perfusion, suggesting a role for endogenous nitric oxide inhibitors in HF-related renal pathology.
Absolute Event Rate: 4.18% vs 2.38%
p-value: p=<0.01
BACKGROUND: Patients with heart failure are characterized by impaired nitric oxide-dependent endothelial vasodilation and, in addition, by reduced renal perfusion. DESIGN: We assessed blood concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) as well as renal haemodynamics to compare normotensive patients with mild heart failure (n = 12, seven males, 70 +/- 1 years, 72.0 +/- 2.7 kg, 92 +/- 2 mmHg, NYHA I/II) and healthy subjects matched with respect to gender, age and body weight (n = 12, seven males, 69 +/- 2 years, 72.7 +/- 2.5 kg, 88 +/- 2 mmHg). RESULTS: Plasma ADMA concentration and renovascular resistance (RVR) were significantly higher (P < 0.01) and effective renal plasma flow (ERPF) significantly lower (P < 0.01) in the patients with heart failure (ADMA 4.18 +/- 0.42 micro mol L-1, RVR 159 +/- 12 mmHg mL-1 min-1, ERPF 381 +/- 26 mL min-1 1.73 m-2) as compared with the healthy controls (ADMA 2.38 +/- 0.11 micro mol L-1, RVR 117 +/- 8 mmHg mL-1 min-1, ERPF 496 +/- 19 mL min-1 1.73 m-2). In contrast, plasma concentrations of l-arginine, homocysteine, symmetric dimethylarginine (i.e. the biologically inactive stereoisomer of ADMA) and plasma renin activity were not significantly different in both groups studied. In the multiple regression analysis, only plasma ADMA concentrations independently predicted reduced ERPF (r = -0.57; P < 0.003). CONCLUSIONS: In normotensive patients with heart failure plasma ADMA concentrations are markedly increased and related to reduced renal perfusion. Thus accumulation of this endogenous nitric oxide inhibitor may play a role in renal pathology in these patients.
Kielstein et al. (Fri,) conducted a case-control in Heart failure (n=24). Mild heart failure vs. Healthy controls was evaluated on Plasma ADMA concentration (micro mol L-1) (p=<0.01). Normotensive patients with mild heart failure had significantly higher plasma ADMA concentrations (4.18 vs 2.38 µmol/L, P<0.01) and reduced effective renal plasma flow compared to healthy controls.