Asymmetrical Dimethylarginine Plasma Concentrations Are Related to Basal Nitric Oxide Release but Not Endothelium-Dependent Vasodilation of Resistance Arteries in Peritoneal Dialysis Patients

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Structured PICO

Population

37 peritoneal dialysis patients

Intervention

Assessment of forearm blood flow responses to acetylcholine, nitroglycerine, and L-NMMA, and measurement of L-arginine and ADMA plasma concentrations

Outcome

Association between ADMA and basal endothelial NO release and endothelium-dependent vasodilation in resistance arteriessurrogate

In peritoneal dialysis patients, elevated ADMA is related to basal NO bioactivity but does not explain impaired endothelium-dependent vasodilation.

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ADMA links to basal NO activity in peritoneal dialysis patients; leaves open its role in endothelial dysfunction and needs prospective confirmation.

Mittermayer et al. (2005) studied this question.

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ADMA links to basal NO activity in peritoneal dialysis patients; leaves open its role in endothelial dysfunction and needs prospective confirmation.