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April 14, 2003CirculationOpen Access

Asymmetric Dimethylarginine, Blood Pressure, and Renal Perfusion in Elderly Subjects

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Population

72 subjects including young healthy, elderly healthy, and elderly subjects with essential hypertension.

Design

Cross-sectional

Authors

JKJan T. KielsteinKlinikum BraunschweigSBStefanie M. Bode‐BögerVascular MedicineJFJürgen C. FrölichVascular Medicine

Discussion

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Implication

ADMA accumulation may contribute to age-related renal hypoperfusion; leaves open whether targeting ADMA alters outcomes in elderly hypertension.

Structured PICO

P
Population
72 subjects including young healthy (n=24, 13 men, age 25+/-1 years), elderly healthy (n=24, 13 men, age 69+/-2 years), and elderly subjects with essential hypertension (n=24, 13 men, age 70+/-2 years).
O
Outcome
Plasma ADMA concentration, renovascular resistance (RVR), and effective renal plasma flow (ERPF)surrogate

Accumulation of the endogenous NO synthase inhibitor ADMA in older individuals is independently associated with decreased renal perfusion and increased blood pressure.

Cite This Study

Kielstein et al. (2003) studied this question.

synapsesocial.com/papers/6a7216e478a11c550e0bf51ehttps://doi.org/10.1161/01.cir.0000060496.23144.a7

Topics

Hypertension management
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