Synthesis, Spectral Characteristics and Molecular Docking Studies of N-(2,2,2-Trichloro-1- Thioureidoethyl)carboxamides

Thiourea and its derivatives are widely used in various fields of human practice. In this work, we report the development of a new, easy-to-implement and highly productive method for synthesizing N-(2,2,2-trichloro-1- thioureidoethyl)carboxamides. These substances were obtained by interacting N-(2,2,2-trichloro-1-isothiocyanatoethyl)carboxamides with ammonia in a chloroform medium. The target products were obtained with 81-92% yield and 1H, 13C NMR and IR spectroscopy reliably proved their structure. All the obtained compounds were tested for their ability to bind to the active site of the GADD34:PP1 holoenzyme using molecular docking.