Synthesis of Novel Aldehydes Suitable for Bioconjugation by Introdaction of a Carboxyl Group via Alkylation of Hydroxybenzaldehydes With Chloroacetic Acid

The communication focuses on the alkylation of hydroxybenzaldehydes by chloroacetic acid to introduce a carboxyl group, and investigates the reactivity of the resulting compounds with semicarbazide and malonodinitrile under acidic or alkaline conditions. Successful alkylation of some hydroxybenzaldehydes with chloroacetic acid was carried out with yields 20-67%. The work demonstrates an effective approach to modifying existing aldehydes to introduce new functional groups, with potential applications in the synthesis of aromatic and heterocyclic compounds for use in various industries.