Key result
The highest tertile of the triglyceride glucose index (above 8.57) was significantly associated with a 1.78-fold higher risk of subclinical atherosclerosis compared to the lowest tertile.
Why the study?
Few studies had examined the relationship between triglyceride/glucose index (TyG index) and atherosclerosis measured by brachial-ankle pulse wave velocity in Japanese adults.
Does a higher triglyceride/glucose index correlate with increased subclinical atherosclerosis (measured by baPWV) in Japanese adults?
Cross-Sectional (n=912)
No
Does a higher triglyceride/glucose index correlate with increased subclinical atherosclerosis (measured by baPWV) in Japanese adults?
Odds Ratio: 1.78 (95% CI 1.08–2.95)
p-value: p=0.024
The triglyceride/glucose index is positively and linearly associated with subclinical atherosclerosis (measured by baPWV) in Japanese adults, suggesting its potential utility as a predictive marker.
May support TyG index for arterial stiffness screening in Japanese adults; hypothesis-generating pending prospective outcome studies.
BACKGROUND: Few studies examined the relationship between triglyceride/glucose index (TyG index) and atherosclerosis in Japanese adults. Therefore, this study evaluated their relationship, as measured based on the brachial-ankle pulse wave velocity (baPWV) in Japanese adults. METHODS: A total of 912 participants was selected from the NAGALA (NAFLD in Gifu Area, Longitudinal Analysis) study conducted from 2004 to 2012. The relationship between the TyG index and baPWV was estimated through a logistic model. Subgroup analyses by sex, age, body mass index (BMI), total cholesterol, low-density lipoprotein cholesterol, estimated glomerular filtration rate (eGFR), and fatty liver was performed. The formula for TyG index was ln (½fasting triglyceride level [mg/dL] × fasting plasma glucose level [mg/dL]). RESULTS: A linear relationship between TyG and baPWV was discovered after adjusting for underlying confounders. An increased risk of baPWV was observed after adjusting for sex, age, BMI, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol, fatty liver, eGFR, and TyG as a continuous variable (adjusted odds ratio [adj OR], 1.57; 95% confidence interval [95% CI], 1.14-2.18). Compared with the TyG index in the first tertile, the probabilities of subjects in the third tertile that developed to baPWV were 1.78-fold higher (adj OR 1.78, 95% CI 1.08-2.95: P for trend 0.024). Moreover, stable associations were observed between the TyG index and baPWV in different variables through subgroup analyses. CONCLUSIONS: The highest tertile (above 8.57) of the TyG index was positively and linearly related to subclinical atherosclerosis in Japanese adults and may be valuable as a predicted marker.
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Yang et al. (2022) conducted a cross-sectional in Subclinical atherosclerosis (n=912). Triglyceride glucose (TyG) index vs. Lowest tertile of TyG index was evaluated on Subclinical atherosclerosis (measured by brachial-ankle pulse wave velocity) (OR 1.78, 95% CI 1.08-2.95, p=0.024). The highest tertile of the triglyceride glucose index (above 8.57) was significantly associated with a 1.78-fold higher risk of subclinical atherosclerosis compared to the lowest tertile.
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