Key result
Highest versus lowest serum GGT quartiles were independently associated with increased arterial stiffness in both men (OR 1.63; 95% CI 1.21-2.20) and women (OR 1.56; 95% CI 1.08-2.27).
Why the study?
Is higher serum gamma-glutamyltransferase (GGT) associated with increased arterial stiffness in healthy individuals?
Cross-Sectional (n=10,988)
No
Is higher serum gamma-glutamyltransferase (GGT) associated with increased arterial stiffness in healthy individuals?
Odds Ratio: 1.63 (95% CI 1.21–2.2)
p-value: p=<0.001
Serum GGT is independently associated with increased arterial stiffness in both healthy men and women, with a potentially stronger association in men.
GGT independently associates with higher baPWV in healthy adults; leaves open whether it adds prognostic value beyond conventional risks in prospective cohorts.
OBJECTIVE: Gamma-glutamyltransferase (GGT) has been reported to be useful in predicting cardiovascular disease. Arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) is not only a marker of vascular damage but a significant predictor of cardiovascular events. Gender difference has been reported in the association between GGT and baPWV. We assessed, therefore, the association between GGT and baPWV in a large population and determined whether there was gender difference. DESIGN: This cross-sectional study was conducted at the Asan Medical Centre, Seoul, Republic of Korea. SUBJECTS AND MEASUREMENTS: Serum GGT, baPWV and conventional risk factors were measured in 10 988 apparently healthy subjects (7248 men, 3740 women) who participated in a routine health screening examination. RESULTS: In both men and women, we observed positive linearity between GGT quartiles and body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides, uric acid, high-sensitive C-reactive protein (hsCRP) and homeostatic model assessment of insulin resistance (HOMA-IR) score (P for trends < 0·001). The proportion of individuals with diabetes, hypertension increased as the GGT quartile increased (P for trends < 0·001). Age-adjusted mean baPWV increased gradually in both males and females according to GGT quartiles (P for trends < 0·001 in both genders). The odds for higher baPWV (i.e. >75th percentile in each sex) were significantly higher in the highest compared with the lowest GGT quartiles, after adjustment for confounding variables, in both men [odds ratio (OR) = 1·63, 95% CI = 1·21-2·20] and women (OR = 1·56, 95% CI = 1·08-2·27). CONCLUSIONS: These results suggest that GGT is independently associated with the increased level of arterial stiffness both in men and in women and the association between them appears to be stronger in men compared to women.
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Jung et al. (2011) conducted a cross-sectional in Healthy subjects (n=10,988). Serum gamma-glutamyltransferase (GGT) vs. Lowest GGT quartile was evaluated on Higher brachial-ankle pulse wave velocity (>75th percentile) (OR 1.63, 95% CI 1.21-2.20, p=<0.001). Highest versus lowest serum GGT quartiles were independently associated with increased arterial stiffness in both men (OR 1.63; 95% CI 1.21-2.20) and women (OR 1.56; 95% CI 1.08-2.27).
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