Key result
Serum gamma-glutamyltransferase was independently associated with increased arterial stiffness in both men (β = 0.017; P < .001) and women (β = 0.015; P < .001) with established CAD.
Observational (n=978)
Effect estimate: β = 0.017 (men), β = 0.015 (women)
p-value: p=<.001
Serum gamma-glutamyltransferase (GGT) levels are independently associated with increased arterial stiffness in both men and women with established coronary artery disease.
GGT may mark arterial stiffness in CAD; hypothesis-generating and should not yet change practice.
Serum gamma-glutamyltransferase (GGT) has been reported to predict vascular risk. We enrolled 978 patients (507 men and 471 women) with established coronary artery disease (CAD). The GGT, brachial-ankle pulse wave velocity ([baPWV] to assess arterial stiffness), and conventional risk factors were evaluated. The means of baPWV tend to increase in both genders according to GGT tertiles. Body mass index, GGT, logarithmical (systolic blood pressure [LnSBP]), uric acid (UA), total bilirubin, Ln (cholinesterase), and Ln (total cholesterol) were correlated with baPWV in men in a multivariate model. However, only GGT, LnSBP, UA, and Ln (high-density lipoprotein cholesterol) were correlated with baPWV in women. The GGT was a significant determinant for increased baPWV both in men (β = 0.017; P < .001) and in women (β = 0.015; P < .001). In conclusion, GGT was independently associated with increased arterial stiffness both in men and in women with established CAD.
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Zhu et al. (2012) conducted an observational in Established coronary artery disease (CAD) (n=978). Serum gamma-glutamyltransferase (GGT) was evaluated on Brachial-ankle pulse wave velocity (baPWV) to assess arterial stiffness (β = 0.017 (men), β = 0.015 (women), p=<.001). Serum gamma-glutamyltransferase was independently associated with increased arterial stiffness in both men (β = 0.017; P < .001) and women (β = 0.015; P < .001) with established CAD.
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