Key result
G-CSF treatment in rats with experimental myocardial infarction improved early post-infarct ventricular expansion through promotion of reparative collagen synthesis in the infarcted area.
Why the study?
Does G-CSF improve early ventricular expansion and reparative fibrosis in a rat model of myocardial infarction?
Population
Male Wistar rats with induced myocardial infarction by ligation of the left coronary artery
Comparison
Granulocyte colony-stimulating factor 20… vs Saline injected subcutaneously 3 h after MI and…
Design
Preclinical
Follow-up
14 days
Authors
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Does not inform clinical post-MI care; leaves open translation of G-CSF effects on remodeling to humans.
Does G-CSF improve early ventricular expansion and reparative fibrosis in a rat model of myocardial infarction?
G-CSF attenuates early post-infarct ventricular expansion by promoting reparative collagen synthesis in a rat model of myocardial infarction.
Sugano et al. (2004) studied Myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) vs. Saline was evaluated on Early ventricular expansion and reparative collagen synthesis. G-CSF treatment in rats with experimental myocardial infarction improved early post-infarct ventricular expansion through promotion of reparative collagen synthesis in the infarcted area.
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