Key result
G-CSF administration after myocardial infarction in rats exacerbated cardiac fibrosis, increased infarct size, induced LV dysfunction, and significantly lowered survival compared to saline.
Why the study?
Does G-CSF administration affect cardiac MMP/TIMP ratios and long-term remodeling in a rat model of acute myocardial infarction?
RCT (n=36)
randomized
Does G-CSF administration affect cardiac MMP/TIMP ratios and long-term remodeling in a rat model of acute myocardial infarction?
In a rat model of myocardial infarction, G-CSF administration exacerbated cardiac fibrosis, infarct expansion, and LV dysfunction, leading to lower survival.
No takes yet. Share an insight, caveat, or question.
G-CSF worsened post-MI remodeling in rats; leaves open human translation and challenges prior safety assumptions.
Cheng et al. (2008) conducted an RCT in Acute myocardial infarction (rat model) (n=36). Granulocyte colony-stimulating factor (G-CSF) vs. Saline was evaluated on Cardiac MMP/TIMP ratios and long-term remodelling (LV enlargement, dysfunction, fibrosis, and survival). G-CSF administration after myocardial infarction in rats exacerbated cardiac fibrosis, increased infarct size, induced LV dysfunction, and significantly lowered survival compared to saline.
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