Elevated serum uric acid in the highest quartile was independently associated with a significantly increased risk of cardiovascular disease (OR 2.37) compared to the lowest quartile.
Observational (n=502)
Yes
Is hyperuricemia independently associated with an increased risk of cardiovascular disease in patients with CVD, hypertension, and/or diabetes?
Serum uric acid is an independent risk factor for cardiovascular disease in a Pakistani Punjabi population, suggesting its potential utility in CVD risk stratification.
Odds Ratio: 2.37 (95% CI 1.72–3.27)
p-value: p=<0.001
It is well-known that serum uric acid (SUA) can increase the risk of hypertension, diabetes, obesity and dyslipidemia. However, its independent association with the risk of cardiovascular diseases (CVD) is controversial particularly in different populations. Hence, this study was aimed to assess an independent association of SUA with CVD risk in a Punjabi Pakistani cohort. This is a retrospective observational study in which 502 human subjects having CVD, hypertension and/or diabetes were grouped based on SUA levels as normouricemia ( n = 266) and hyperuricemia ( n = 236). Role of SUA was assessed in increasing the risk of CVD independent of other key confounding factors (i.e. age, gender, dyslipidemia, hypertension, diabetes, dietary and life-style habits). All clinical and biochemical data were analyzed in SPSS (ver. 20). Subjects aged 55 ± 13 years were of both genders (males: 52%). SUA levels were significantly different among clinical subtypes of CVD i.e. acute coronary syndrome (ACS), myocardial infarction (MI) and heart failure (HF). Spearman correlation showed a significantly positive association between CVD and SUA (rho = 0.149, p < 0.001). Multivariate logistic regression of SUA quartiles showed that hyperuricemia is associated with CVD 3 rd quartile: OR: 1.78 (CI: 1.28–2.48), p = 0.001 and 4 th quartile: OR: 2.37 (CI: 1.72–3.27), p < 0.001. Moreover, this association remained significant even after adjusting for confounding factors. This study showed that SUA is positively associated with CVD, thus it can act as an independent risk factor for CVD.
Hussain et al. (Wed,) conducted a observational in Cardiovascular diseases, hypertension, and/or diabetes (n=502). Elevated serum uric acid (Hyperuricemia) vs. Normouricemia (or lowest serum uric acid quartile) was evaluated on Cardiovascular disease risk (OR 2.37, 95% CI 1.72-3.27, p=<0.001). Elevated serum uric acid in the highest quartile was independently associated with a significantly increased risk of cardiovascular disease (OR 2.37) compared to the lowest quartile.