Key result
Right ventricular septal and His-bundle pacing offer promising physiological alternatives to right ventricular apical pacing, which is associated with left ventricular dysfunction and heart failure.
Why the study?
Do alternative sites of ventricular pacing (RV septum and His bundle) prevent negative effects on ventricular function and hemodynamics compared to RV apical pacing in patients needing long-term ventricular pacing?
Do alternative sites of ventricular pacing (RV septum and His bundle) prevent negative effects on ventricular function and hemodynamics compared to RV apical pacing in patients needing long-term ventricular pacing?
This review highlights the paradigm shift from traditional right ventricular apical pacing to alternative sites such as the RV septum and His bundle to mitigate pacing-induced ventricular dyssynchrony.
May support physiological pacing in select patients; leaves open confirmation of long-term benefits in randomized trials.
The right ventricular (RV) apex has been considered to be the primary site for ventricular lead implantation since the original descriptions of permanent pacing. However, long-term RV apical pacing has been shown to have negative effects on ventricular function and hemodynamics as a result of ventricular dyssynchrony. Alternative sites of ventricular pacing, particularly the RV septum and His bundle, have been evaluated for patients with a need for long-term ventricular pacing. In this article, we review the available data on the use of these alternative sites for RV pacing.
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Worsnick et al. (2018) conducted a review in Bradyarrhythmias requiring ventricular pacing. Right ventricular non-apical pacing (septal and His-bundle) vs. Right ventricular apical pacing was evaluated. Right ventricular septal and His-bundle pacing offer promising physiological alternatives to right ventricular apical pacing, which is associated with left ventricular dysfunction and heart failure.
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