Key result
Phytonadione and clotting factor concentrates appear useful for warfarin reversal, while limited evidence suggests a potential role in reversing target-specific oral anticoagulants in emergencies.
Why the study?
What are the pharmacologic agents and strategies used for urgent reversal of oral anticoagulants?
Population
Patients who are bleeding or need surgery while on oral anticoagulants
Design
Review
Authors
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May inform emergency warfarin reversal with phytonadione and concentrates; leaves open optimal strategies and dosing for target-specific oral anticoagulants.
What are the pharmacologic agents and strategies used for urgent reversal of oral anticoagulants?
Clotting factor concentrates and phytonadione are useful for warfarin reversal, with limited evidence supporting their use for target-specific oral anticoagulants.
James S. Kalus (2013) conducted a review in Patients requiring urgent reversal of oral anticoagulants. Pharmacologic reversal agents (phytonadione, FFP, PCC, rFVIIa, aPCC) was evaluated. Phytonadione and clotting factor concentrates appear useful for warfarin reversal, while limited evidence suggests a potential role in reversing target-specific oral anticoagulants in emergencies.
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