May 1, 2020HämostaseologieOpen Access

How Do I Reverse Oral and Parenteral Anticoagulants?

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Why the study?

Recent diversification in licensed anticoagulants makes an understanding of drug-specific reversal strategies essential to safely care for patients facing bleeding or invasive procedures.

Design

Review

Authors

JKJürgen KoscielnyCharité - Universitätsmedizin Berlin EREdita Rutkauskaite CSChristoph SuckerHeidelberg University

Discussion

Member takes

Implication

Emphasizes drug-specific reversal for safe care in bleeding or procedures; leaves open optimal strategies for newer agents.

Structured PICO

Population

Patients on oral or parenteral anticoagulants (vitamin K antagonists, direct oral anticoagulants, heparins) presenting with severe bleeding, requiring urgent invasive procedures, or with anticoagulant overdose.

Intervention

Drug-specific reversal strategies including vitamin K, prothrombin complex concentrate (PCC), protamine, idarucizumab, and andexanet alfa, along with general hemostatic management.

Understanding drug-specific reversal strategies and appropriate hemostatic management is essential for safely treating patients on anticoagulants who experience severe bleeding or require urgent surgery.

Cite This Study

Koscielny et al. (2020) studied this question.

synapsesocial.com/papers/6a7cc672cc6f1443deba673d https://doi.org/10.1055/a-1113-0557

Topics

Anticoagulation in AF

View Full Paper

Ask AI

Bookmark

How Do I Reverse Oral and Parenteral Anticoagulants?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

How Do I Reverse Oral and Parenteral Anticoagulants?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider