Key result
Intravenous vitamin K achieved an INR of 2 or less within 12 hours in 44% of administration events compared to 14% with oral vitamin K for warfarin reversal (p<0.01).
Why the study?
Does intravenous vitamin K compared to oral vitamin K improve the speed of warfarin reversal in patients requiring INR correction?
Observational (n=135)
Does intravenous vitamin K compared to oral vitamin K improve the speed of warfarin reversal in patients requiring INR correction?
Absolute Event Rate: 44% vs 14%
p-value: p=<0.01
Intravenous vitamin K is significantly more effective than oral administration for achieving urgent partial correction of warfarin (INR ≤ 2 within 12 hours).
No takes yet. Share an insight, caveat, or question.
IV vitamin K may accelerate partial warfarin reversal; leaves open need for randomized outcome trials before practice change.
Meehan et al. (2012) conducted an observational in Warfarin reversal (n=135). Intravenous vitamin K vs. Oral vitamin K was evaluated on Achieving an INR of 2 or less within 12 hours (p=<0.01). Intravenous vitamin K achieved an INR of 2 or less within 12 hours in 44% of administration events compared to 14% with oral vitamin K for warfarin reversal (p<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: