Why the study?
Does individualized vitamin K dosing improve target INR achievement at 24 hours in asymptomatic or mildly haemorrhagic over-anticoagulated patients on warfarin compared to fixed-dose algorithms?
Does individualized vitamin K dosing improve target INR achievement at 24 hours in asymptomatic or mildly haemorrhagic over-anticoagulated patients on warfarin compared to fixed-dose algorithms?
Current fixed-dose vitamin K algorithms for warfarin reversal are inadequate for many patients, highlighting the need for individualized dosing based on patient-specific clinical and genetic factors.
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Fixed-dose algorithms leave over one-third outside target INR at 24 hours; hypothesis-generating for individualized dosing trials.
Sconce et al. (2006) studied this question.
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