Key result
Higher TyG index linked to ~32% higher depression risk per unit in hypertensive adults.
Why the study?
Hypertensive individuals have an increased risk of depression, but the association between the triglyceride glucose index and depression in this population remains unclear.
Does a higher triglyceride glucose index increase the risk of depression in adults with hypertension?
Cross-Sectional (n=5,897)
Does a higher triglyceride glucose index increase the risk of depression in adults with hypertension?
Odds Ratio: 1.32 (95% CI 1.12–1.54)
p-value: p=0.0012
The TyG index, a simple marker of insulin resistance, is nonlinearly associated with a higher risk of depression in hypertensive adults.
TyG index associated with depression in hypertension; hypothesis-generating and requires prospective validation before any clinical use.
Growing evidence suggests that hypertensive individuals have a greater risk of developing depression, and depression can also increase the incidence of hypertension. In the hypertensive population, the association between triglyceride glucose (TyG) index and depression remains unclear. This study aimed to assess the association between TyG index and depression in hypertensive people through the cross-sectional study of the National Health and Nutrition Examination Survey (2007-2018). To assess the relationship between TyG index and depression in hypertensive population, we conducted weighted multiple logistic regression models and used a generalized additive model to probe for nonlinear correlations. In addition, we employed a recursive algorithm to determine the inflection point and established a two-piece linear regression model. This study enrolled 5897 individuals. In the model adjusted for all covariates, the ORs (95% CI) for the relationship between TyG index and depression in hypertensive population were 1.32 (1.12-1.54). A nonlinear association was found between TyG index and depression, with an inflection point at 8.7. After the inflection point, the ORs (95% CI) were 1.44 (1.15-1.79). Only the interaction with the obese population was statistically significant. Our study highlighted a nonlinear association between TyG index and depression in American hypertensive adults.
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Zhang et al. (2024) conducted a cross-sectional in Hypertension (n=5,897). Triglyceride glucose (TyG) index vs. Lower TyG index was evaluated on Depression (assessed by PHQ-9 score ≥10) (OR 1.32, 95% CI 1.12-1.54, p=0.0012). A higher triglyceride glucose index was associated with an increased risk of depression in American hypertensive adults, with an OR of 1.32 per unit increase in the fully adjusted model.
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