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March 1, 2026Research and Practice in Thrombosis and HaemostasisOpen Access

Clinician perspectives on antithrombotic therapy management in advanced cancer: a multinational qualitative study

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Key result

Clinicians managing antithrombotics in advanced cancer report role ambiguity and a passive culture of continuation.

  • n=80

Why the study?

Antithrombotic therapy decision-making near the end of life in advanced cancer involves clinical uncertainty and blurred specialty roles, but clinicians' perspectives remain largely underexplored.

Design

Multinational qualitative semistructured interview study

Authors

EBElin BaddeleyCardiff UniversityCFCarme FontIMIsabelle Mahé

Discussion

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Member takes

Overview

Supports caution against passive antithrombotic continuation in advanced cancer; leaves open optimal deprescribing strategies for prospective study.

Structured PICO

P
Population
80 clinicians across various specialties involved in antithrombotic therapy management for patients with advanced cancer at the end of life.
E
Exposure
Semistructured interviews exploring experiences of continuing and deprescribing antithrombotic therapy.
O
Outcome
Clinicians' experiences and perspectives on current practice of continuing and deprescribing antithrombotic therapy.

Clinicians face significant complexities and ambiguity in managing antithrombotic therapy for advanced cancer patients at the end of life, often defaulting to a culture of continuation.

Cite This Study

Baddeley et al. (2026) studied Advanced cancer at the end of life (n=80). Antithrombotic therapy management was evaluated on Clinicians' experiences of current practice of continuing and deprescribing ATT. Clinicians managing antithrombotic therapy in advanced cancer reported challenges including role ambiguity, timing delicacy, and a culture of continuation leading to passivity in therapy review.

synapsesocial.com/papers/6a622fc9da6914d0ce89acf7https://doi.org/10.1016/j.rpth.2026.103427
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1“Who am I to say that I'm not going to take it”: patient perspectives on decisions about antithrombotic therapy in the context of advanced cancer2025 · 3 citations
  2. 2Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer2024 · 10 citations
  3. 3Anti‐thrombotic therapy in patients with cancer at the end of life and associated clinical outcomes: A cohort study using population‐linked routinely collected data2025
  4. 4Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis2025
  5. 5When is it time to bid farewell to anticoagulation?2025