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August 25, 2025PLoS MedicineOpen Access

Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis

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Authors

JJJustin JagoshMPMark PearsonSGSarah Greenley

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Overview

Realist synthesis reveals factors affecting antithrombotic therapy deprescribing in cancer patients, suggesting improved shared decision-making processes.

Key Points

  • Deprescribing antithrombotic therapy reduces risks and enhances patient safety during end-of-life care.
  • Key insights show clinician engagement and medication meaning influence patient involvement in shared decision-making.
  • Realist synthesis examined multiple study types and highlighted prescribing inertia in antithrombotic therapy management.
  • Multi-disciplinary approaches and organizational investment can address challenges and improve decision-making in palliative care.

Cite This Study

Jagosh et al. (2025) studied this question.

synapsesocial.com/papers/68af5f0dad7bf08b1eae1b43https://doi.org/10.1371/journal.pmed.1004663
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study2025 · 2 citations
  2. 2Factors influencing deprescribing in community-dwelling patients with palliative needs in primary care: A qualitative systematic review2026
  3. 3244 Deprescribing and shared decision-making research2024
  4. 4Clinician perspectives on antithrombotic therapy management in advanced cancer: a multinational qualitative study2026
  5. 5Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer2024 · 10 citations