Key result
Low-molecular weight heparin prophylaxis in acutely ill medical inpatients prevented 48% of symptomatic pulmonary embolism and 51% of asymptomatic deep vein thrombosis.
Why the study?
Does low-molecular weight heparin prophylaxis reduce the risk of venous thromboembolism in acutely ill medical inpatients?
Population
Acutely ill medical inpatients (7 blinded RCTs)
Design
Meta-analysis, Included studies were randomized, Included studies were blinded
Authors
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May inform VTE prophylaxis decisions in medical inpatients; leaves open optimal use pending consistent randomized data.
Meta-Analysis
Does low-molecular weight heparin prophylaxis reduce the risk of venous thromboembolism in acutely ill medical inpatients?
Effect estimate: 48% reduction in symptomatic PE, 51% reduction in asymptomatic DVT
LMWH prophylaxis in acutely ill medical inpatients reduces the risk of symptomatic PE and asymptomatic DVT by approximately half, though with a nonsignificant trend toward increased bleeding.
Själander et al. (2007) conducted a meta-analysis in Acutely ill medical inpatients at risk of venous thromboembolism. Low-molecular weight heparin (LMWH) prophylaxis was evaluated on Symptomatic pulmonary embolism (PE), symptomatic deep vein thrombosis (DVT), and asymptomatic DVT (48% reduction in symptomatic PE, 51% reduction in asymptomatic DVT). Low-molecular weight heparin prophylaxis in acutely ill medical inpatients prevented 48% of symptomatic pulmonary embolism and 51% of asymptomatic deep vein thrombosis.
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