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The study investigates the role of Amadori albumin in vascular complications and its association with diabetic nephropathy in type 1 diabetes.

December 1, 1999Diabetes

Amadori albumin in type 1 diabetic patients: correlation with markers of endothelial function, association with diabetic nephropathy, and localization in retinal capillaries.

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Randomized trial shows higher Amadori albumin levels correlate with endothelial dysfunction in type 1 diabetes, indicating potential complications.

The study investigates the role of Amadori albumin in vascular complications and its association with diabetic nephropathy in type 1 diabetes.
Developed antiserum against glycated human serum albumin (HSA) to study early glycation products.
Analyzed plasma Amadori albumin levels in type 1 diabetic patients (n=55) and healthy controls (n=60).
Evaluated plasma Amadori albumin levels in long-standing diabetic patients with (n=199) and without (n=192) nephropathy.
Type 1 diabetic patients had higher Amadori albumin levels (39.2+/−9.9 U/ml) compared to controls (20.9+/−4.0 U/ml, P < 0.0005).
Amadori albumin correlated with von Willebrand factor (r=0.29, P < 0.05) and vascular cell adhesion molecule-1 (r=0.41, P < 0.005).
Patients with nephropathy had higher Amadori albumin levels (50.9+/−9.5 U/ml) compared to those without (45.1+/−6.3 U/ml, P < 0.0005).

Schalkwijk et al. (1999) studied this question.

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Randomized trial shows higher Amadori albumin levels correlate with endothelial dysfunction in type 1 diabetes, indicating potential complications.